CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety.

TRANSCRIPT:

CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own.

CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood.

CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy.

REFERENCES:

Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250

McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944

Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041

World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

Special thanks to Srikar Gade for help with fact-checking this video.

source

The Dr. Greenthumb Podcast #340

The Dr. Greenthumb Podcast #340

Powered by Restream https://restream.io/ The Dr. Greenthumb Podcast 340 0:00 - stream starts 14:00 - Podcast Starts 16:00 - doc talk 30:00 - percussions 39:00 - Bogart the stash 45:00 - globbing 58:00 - Snobby Sesh 1:03:00 - NYC Delivery 1:15:00 - Chuck D Public Enemy...

CBD changing the game for athletes

CBD changing the game for athletes

Even though Senate Bill 57 legalized hemp products in Ohio, Akron Marathon organizers do not expect any vendors to have CBD products for runners to sample or buy. source

CBD American Shaman Hobbs | CBD Near Me Hobbs NM 88240

CBD American Shaman Hobbs | CBD Near Me Hobbs NM 88240

CBD Near Me Hobbs NM | CBD American Shaman Hobbs 927 E Bender Blvd. Hobbs, NM 88240 (575) 659-8515 - https://cbdstorehobbs.com We're a local CBD Oil store in Hobbs, New Mexico with a full line of 100% Organic Full-Spectrum CBD Hemp oil products. We’re proud to be part...